Ekaislot specializes in designing, manufacturing, and installing packing and tray column internals, offering tailored distillation solutions for efficient separation processes.
Pressure Vessel Throughout the entire manufacturing process, we adhere to stringent quality control procedures. Our pressure vessels are capable of withstanding extremely high internal and external pressures and are suitable for a wide variety of application scenarios.
Ekaislot is ISO9001 certified and ASME authorized, ensuring that all products comply with international standards for quality and safety. All products are covered by our strict quality control methodology.
SpaciousFacilities
Ekaislot operates extensive facilities totaling 8600 m² for processing, 3000 m² for clean production, and 1200 m² for office space in Shanghai and Nantong, supporting high-quality manufacturing.
OUR STRENGTHS
ExpertTechnical Background
With over 12 years of experience, Ekaislot specializes in developing column and reactor internals and holds multiple patents to enhance the efficiency of distillation columns and separators.
ComprehensiveService and Support
The company provides complete solutions, including on-site installation and robust after-sales support, ensuring the efficient and reliable performance of reactor internals, distillation columns and filters in real-world applications.
Nitrification is the process of introducing nitro groups to organic molecules and has wide applications in the chemical industry, especially in explosives and energetic materials manufacturing. The introduction of nitro into aromatic rings and heterocycles serves three main purposes: converting nitro to other substituents, activating other groups on the aromatic ring, and giving fine - chemical products specific properties. The nitrification process has two types: batch and continuous. The batch process has production risks due to post - reaction raw material reactions, while the continuous process improves efficiency and reduces labor intensity but has a low industry application proportion. Some companies stick to the batch process for flexible adjustment according to market changes, and many lack awareness of nitrification hazards. Local governments have introduced strict policies to ensure safety. Micro - chemical technology, represented by the microchannel reactor, is a new environmentally friendly chemical technology. It offers effective solutions for nitrification reactions with its small area, reasonable resource utilization, and low energy consumption. Examples show its high efficiency, safety, and product selectivity in nitrification reactions. In conclusion, the continuous flow reactor has significant advantages in the dangerous nitrification process, achieving intrinsic safety and revolutionizing chemical production.
In a distillation column, internal reflux is the downward - flowing liquid from the top, formed by a pump at the bottom drawing overhead liquid and re - injecting it. It can reduce top - column concentration, improve distillation liquid efficiency and product quality, but it increases equipment cost and maintenance expenses, and improper control may cause negative effects. External reflux is the upward - flowing liquid from the bottom, achieved by a separator or level regulator. It can improve separation efficiency and save equipment and maintenance costs, yet it increases the liquid's bubble point, may reduce distillation efficiency, and excessive reflux can cause problems. Both internal and external reflux have pros and cons, and the choice depends on specific operational needs; for demanding distillation, a combination of the two is often used for optimal separation.
The text focuses on the quality control and regulatory framework for continuous flow pharmaceuticals. The ICH Q13 guidelines have core requirements including batch definition adaptable to market demands, Process Analytical Technology for online parameter monitoring, and equipment validation for over 100 - hour continuous operation. A typical case is the continuous synthesis of tetrazoles with optimization strategies to increase yield and ensure process safety. There are technical challenges such as reaction system compatibility, equipment congestion and high maintenance costs, and regulatory lag. Solutions involve modular design, innovative materials, clean - in - place systems, FDA's CQA database, and industry collaboration. Future trends include intelligent integration with AI, expansion of green chemistry, biopharmaceutical fusion, and the development of modular factories.
Continuous Flow Technology (CFT) achieves chemical reaction process continuity via equipment like microchannel reactors and fixed beds. Its core advantages are process intensification and precise control, different from traditional batch production. Continuous flow microreactors can solve user pain - points, including increased safety, efficiency breakthrough, consistent quality, and green manufacturing. In pharmaceutical production, CFT can be classified according to reaction systems: gas - liquid reaction system (e.g., carbonylation reactions with a tube - in - tube device for mixing), solid - liquid reaction system (e.g., palladium - catalyzed Suzuki coupling with a long - life catalyst in a fixed - bed reactor), gas - liquid - solid reaction system (e.g., continuous hydrogenation with integrated water electrolysis hydrogen production and extended to deuterated drug synthesis), liquid - liquid reaction system (e.g., Bucherer - Bergs reaction with high - pressure intensification), and multi - phase integrated system (e.g., SPS - FLOW system for automated production of Prexasertib and synthesis of tetrazoloid derivatives).